|
|
 |
|
Environment and health
|
|
|
|
|
| |
Alternatives to animal testing |
 |
| |
The research in alternatives to animal testing covers all 3R's:
The replacement research includes developing a battery of in vitro models covering many endocrine disrupting mechanisms and a large effort of the development and use of (Q)SARs. In vitro models are also used to investigate genotoxicity, allergy and nanotoxicology.
The replacement and refinement research concern the use of sensitive markers of endocrine disrupting effects such as hormone levels and gene expressions in order to be able to use fewer animals in testing.
The in vitro battery includes the following assays: activation of the androgen receptor (AR assay), the thyroidea receptor (T-screen), the PPAR alpha and gamma receptors, the AhR receptor as well as effects on adipocyte differentiation (3T3-L1), embryotoxicity assay (EST) and for effects on the steroid synthesis (H295R) thus covering steroid action, obesity endpoints and developmental effects. In addition, we investigate the internal metabolism of chemicals in vitro as well as the use of external metabolic systems.
Collaborations
 |
University of Copenhagen, Denmark |
|
University of Southern Denmark |
|
Aarhus University, Denmark |
|
Rigshospitalet, Denmark |
|
International partners in the EU project Contamed |
Contact for further information
Senior scientist, research manager Christine Nellemann |
| |
|
|
|
|
|
|
|
| |
